Dahlia flower extract may help control blood sugar
- Dahlia petals contain three molecules that together may help people with prediabetes or prediabetes control their blood sugar levels, according to new research.
- These molecules reduce brain inflammation, which in turn improves insulin function.
- This discovery may provide a measure of blood sugar control for millions of people around the world who lack access to expensive and often unavailable medications.
Dahlias, D- Pinnateare more than just beautifully symmetrical flowers.
A new study describes three molecules found in the petals of these flowers that may improve blood sugar regulation in people with prediabetes and type 2 diabetes.
During a randomized, controlled, crossover clinical trial, researchers found that an extract containing the three dahlia molecules led to significant improvement in blood sugar regulation in study participants.
In 2015, the study authors, from the University of Otago in Aotearoa – the Maori name for New Zealand – demonstrated that a dietary flavonoid called biotin could reduce brain inflammation and that this could improve blood sugar levels in people with blood problems. Control sugar level.
The new study identifies dahlia flower petals as a source of butin and two other molecules that enhance its effectiveness.
The study is published in Oxford academic life metabolism.
Study author Dr. Alexander Tops said the realization that dahlias might provide the poutine his team was looking for was somewhat random. He mentioned this to a colleague over coffee, and he then asked him: “Did you know that dahlias may contain this molecule?”
“This was the beginning of a wonderful journey: international dahlia experts were growing dahlias in the far south of New Zealand, and they were happy to supply the flowers,” Dr Toups said.
The team formulated an extract containing biotin and successfully tested it on mice. Through collaboration with a team of plant chemistry experts, two other molecules that could enhance the effects of biotin were identified.
Researchers in a preclinical setting determined that all three molecules were required to improve the blood sugar lowering effect.
“We could furthermore show that they (the molecules) helped reduce brain inflammation in mice, and that the glucose-lowering effect was dependent on its effect in the brain.”
– Dr. Alexander Tops
Human trials found that the extract produced no noticeable side effects and was effective.
The team has since patented their discovery, published their findings, and brought an extract to improve blood sugar control to the market called Dahlia4. Dahlia4 is available in tablet form. It has not yet been evaluated by the US Food and Drug Administration.
Dr. Thomas Lutz, professor of veterinary physiology at the University of Zurich, who was not involved in the study, noted that there are other plant extracts that have been identified and investigated, but “the question is always about their availability and effectiveness.” and potential toxicity.”
“In these aspects, I see great value in the discovery made here,” Dr. Lutz said.
Blood sugar control may not be all there is to Dahlia’s molecules, Dr. Toups said.
“Because it has shown promise in helping improve brain function, we are now conducting a clinical trial in people with chronic fatigue syndrome or long Covid syndrome,” he said.
“We know that ‘encephalitis’ is associated with many metabolic disorders, for example, access to energy-dense and high-fat foods, obesity, and type 2 diabetes,” Dr. Lutz explained.
He continued: “It has been shown that reducing brain inflammation leads to improvement/restoration of sensitivity to various hormones involved in the physiological control of metabolism, especially insulin and leptin.”
“This concept has been known for many years. The question was how it could be addressed in a way that was beneficial to the patients involved,” said Dr. Lutz.
According to Dr. Lutz, “The discovery described here has the potential to be useful to a very large number of people.”
Aside from the new dahlia extract, he explained that there are several treatment options currently under pre-clinical or clinical research or that have recently received approval.
“Many of these approaches are pharmacological and rely on endogenous hormone agonists,” he said, before adding: “Efficacy and safety are very good, (but) the cost is high, and availability has been an issue.”
“Here we are not talking about drugs (from a legal perspective), but about food additives. This could be beneficial for their widespread use,” said Dr. Lutz.
“Globally, there are millions of people who could benefit from supporting healthy blood sugar and insulin levels.” Dr. Toups said.
“This discovery is therefore important for all patients with metabolic diseases, especially type 2 diabetes, but likely other diseases as well, in which encephalitis plays a role.”
– Dr. Thomas Lutz
Of these, the CDC estimates that 8.5 million people have not yet been diagnosed. The World Health Organization says so
Uncontrolled diabetes can lead to kidney failure, blindness, strokes, heart attacks, and lower limb amputations.
Avoiding such outcomes depends on continuous monitoring of blood sugar, lifestyle changes, and taking insulin or medications that can help control blood sugar.