Salviamilthone AO, a diterpenoid quinone from Salvia miltiorrhiza

Salviamilthone AO, a diterpenoid quinone from Salvia miltiorrhiza

Sex Salvia It belongs to the Lamiaceae family and consists of about 1000 species distributed in temperate and subtropical regions of the world (Hatfield et al., 2018). Many Oral species have been used as folk medicines worldwide to treat angina, thromboembolism, heart failure, venous insufficiency, and pulmonary fibrosis ( Xu et al., 2019 ; Cheng et al., 2012 ; Dou et al., 2022 ). Nwafor et al., 2021; Gu et al., 2022; Previous studies on Bacteroidetes species have reported a large number of natural products containing diterpenoids, iridoids, phenols, flavonoids, steroids, and alkaloids (Yin et al., 2021; Ren et al., 2022a, Ren et al., 2022b, 2023; Lu et al., 2021; Luo et al., 2023). Root Salvia miltiorrhiza, commonly known as “Danshen”, is a traditional Chinese medicine known to treat menstrual disorders, chronic renal failure, hepatitis, dysmenorrhea, cardiovascular diseases, and other diseases ( Li et al., 2023 ; Lu et al., 2021 ). ; Imanshahidi and Hosseinzadeh, 2006; Mei et al., 2019; Ren et al., 2019; Diterpenoids share a basic structure of 20 carbon atoms arranged in rings, and are one group of the main bioactive components in… s. miltiorrhiza. However, diterpenoids, especially tanshinone, are mainly produced in the roots of the title plant ( Lu et al., 2021 ). Phytochemical investigations on s. miltiorrhiza More than 100 diterpenoids with numerous biological activities have been identified. According to the structural characteristics, diterpenoids in s. miltiorrhiza They are further classified into two subgroups. One subgroup is the tanshinones, which are the most abundant diterpenoids and contain a common group Ortho– Naphthoquinone chromophore. The other subgroup contains the roylianones, which are apetane diterpenes colocalized with the naphthoquinone chromophore ( Mei et al., 2019 ).

Acute lung injury (ALI) is a serious respiratory disorder that causes diffuse alveolar injury and high mortality rates due to lack of effective treatment. s. miltiorrhiza It has a protective effect on ALI, but the mechanism is still unclear ( Chen et al., 2020 ). In previous studies, undescribed diterpenoid quinones that have lung protective activity have been isolated ( Ren et al., 2022a , Ren et al., 2022b , 2023 ; Zhang et al., 2022 ). In order to obtain non-prescribed biologically active components, roots s. miltiorrhiza Further investigation was performed to identify 15 undescribed diterpenoid quinones, along with three known compounds, and their lung protective activity was evaluated in lipopolysaccharide (LPS)-transduced BEAS-2B cells, as previously described.

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